#Statistical calculations for trials how to

, Two possible reasons for its absence in anesthesia research are followings: ,, Lack of sample size calculations in prospective studies and power analysis in studies with negative results have sufficiently supported this finding. Proper study design that is an integral component of any randomized clinical trial (i.e., the highest level of evidence available for evaluating new therapies), appears infrequently in the anesthesia literature. Basic concepts for sample size calculation: Critical step for any clinical trials!.

#Statistical calculations for trials how to

How to cite this URL: Gupta K K, Attri J P, Singh A, Kaur H, Kaur G. How to cite this article: Gupta K K, Attri J P, Singh A, Kaur H, Kaur G. Keywords: Clinical trial power of study sample size

We have highlighted the basic concepts regarding various parameters needed to calculate the sample size along with examples. In this review, we will discuss how important sample size calculation is for research studies and the effects of underestimation or overestimation of sample size on project's results. Although statisticians play a major role in sample size estimation basic knowledge regarding sample size calculation is very sparse among most of the anesthesiologists related to research including under trainee doctors. The sample size is one of the basic steps in planning any clinical trial and any negligence in its calculation may lead to rejection of true findings and false results may get approval. Quality of clinical trials has improved steadily over last two decades, but certain areas in trial methodology still require special attention like in sample size calculation.